Avignon lies on the South of France and on the bank of the river Rhône. The city holds a whole lot of medieval and historic content.
It is known as the City of Popes, because in the 14th century it was the seat of the Pope and was used as a fortress and a palace as well. Popes came here because they were fleeing from the Vatican’s political wars.
Another really famous sight is the Bridge of Saint-Bénezet or more commonly known as the Bridge of Avignon which has never been renovated completely. It was built in the 12th century to shorten the trading routes but because of floods it was damaged severely and after the 1600s it was not renovated anymore. There are a lot of museums, maybe the most well-known are: the Calvet Museum, the Lambert Collection and the Angladon Museum.
The possibility of car renting is really necessary because from the Old Town you might have to move by car between museums. You also have to get to the city by car if you come by plane, since the Avignon-Coument airport is not in the middle of the city, and if you already managed to absorb everything of Avignon, you might want to visit Marseille which is only a one-hour car ride, and it is a very iconic French city as well.